DRUG INTERACTIONS

See full prescribing information for TADALAFIL TABLETS.TADALAFIL tablets for oral use.Initial U.S.

• Some people may experience nasal congestion or dizziness.
• Use caution when combining with other erectile dysfunction drugs.
• Always keep medication out of reach of children.

Approval: 2003RECENT MAJOR CHANGESWarnings and Precautions () 05/2017INDICATIONS AND USAGETadalafil tablets are a phosphodiesterase 5 (PDE5) inhibitor indicated for the treatment of: (1)•erectile dysfunction (ED) ()•the signs and symptoms of benign prostatic

hyperplasia (BPH) ()•ED and the signs and symptoms of BPH (ED/BPH) ()If tadalafil tablets are used

16.1 How Supplied

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Does tadalafil interact with other medicines (drug interactions)?

Screening modestly reduces prostate cancer deaths 11 May 2026Blood tests to detect potential signs of prostate cancer likely reduce the risk of dying from prostate cancer, an updated Cochrane review finds. This is a shift from the previous version of the review. Blood tests to detect potential signs of prostate cancer likely reduce the risk of dying from prostate cancer, an updated Cochrane review finds. If you are a consumer or patient please visit this version. HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use TADALAFIL TABLETS safely and effectively. with finasteride to initiate BPH treatment, such use is recommended for up to 26 weeks ().

(1)DOSAGE AND ADMINISTRATION•Tadalafil tablets for use as needed:•ED: Starting dose: 10 mg as needed prior to sexual activity.

8.6 Hepatic Impairment

Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug are: Tadalafil can cause a serious drop in your blood pressure when used with nitrates, which can lead to dizziness, fainting, and rarely heart attack or stroke. Do not use any of the following with tadalafil or within 48 hours of your last dose of tadalafil: certain drugs used to treat chest pain/angina (nitrates such as nitroglycerin, isosorbide) recreational drugs called "poppers" containing amyl or butyl nitrite If you are also taking an alpha blocker medication (such as doxazosin, tamsulosin) to treat an enlarged prostate/BPH or high blood pressure, your blood pressure may get too low which can lead to dizziness or fainting. Your doctor may start treatment with a lower dose of tadalafil or adjust your alpha blocker medication to minimize your risk of low blood pressure.

Product ESCITALOPRAM / 5 mg; 10 mg; 20 mg Tablet; 10 mg/ml oral drops

Other medications can affect the removal of tadalafil from your body, which may affect how tadalafil works. Examples include azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as clarithromycin, erythromycin), HIV protease inhibitors (such as fosamprenavir), rifampin, ritonavir, among others. Do not take this medication with any other product that contains tadalafil or other similar medications used to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, vardenafil). If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. Increase to 20 mg or decrease to 5 mg based upon efficacy/tolerability.

14.1 Tadalafil Tablets for Use as Needed for ED

US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669. Do not share this medication with others. If you are taking this medication on a regular schedule and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose.

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Take your next dose at the regular time. Do not double the dose to catch up. Store at room temperature away from light and moisture. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Improves erectile function compared to placebo up to 36 hours post dose.

• The drug is available by prescription only.
• It is essential to discuss health history with your doctor.
• Not suitable for individuals with certain eye or heart conditions.

Not to be taken more than once per day ().•Tadalafil tablets for once

Shipping & Delivery

Headache, stomach upset, back pain, muscle pain, stuffy nose, flushing, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

More common

Sexual activity may put extra strain on your heart, especially if you have heart problems. If you have heart problems and experience any of these serious side effects while having sex, stop and get medical help right away: Rarely, sudden decreased vision, including permanent blindness, in one or both eyes (NAION) may occur. If this serious problem occurs, stop taking tadalafil and get medical help right away. You have a slightly greater chance of developing NAION if you have heart disease, diabetes, high cholesterol, certain other eye problems ("crowded disk"), high blood pressure, if you are over 50, or if you smoke. Rarely, a sudden decrease or loss of hearing, sometimes with ringing in the ears and dizziness, may occur. daily use:•ED: 2.5 mg taken once daily, without regard to timing of sexual activity.

17.10 Sexually Transmitted Disease

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as heart attack or life-threatening irregular heartbeat in the past 6 months, chest pain/angina, heart failure) penis conditions (such tadalafil over the counter uk as angulation, fibrosis/scarring, Peyronie's disease) conditions that may increase the risk of priapism (such as sickle cell anemia, leukemia, multiple myeloma) eye problems (such as retinitis pigmentosa, sudden decreased vision, NAION) Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This brand of the drug is not usually used in women.

What are the serious side effects of tadalafil?

During pregnancy, tadalafil should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this medication passes into breast milk. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. May increase to 5 mg based upon efficacy and tolerability ().•BPH: 5 mg, taken

17.4 Concomitant Use with Drugs Which Lower Blood Pressure

Stop taking tadalafil and get medical help right away if these effects occur. In the rare event you have a painful or prolonged erection lasting 4 or more hours, stop using this drug and get medical help right away, or permanent problems could occur. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: itching/swelling (especially of the face/tongue/throat) This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Corresponding author

You may report side effects to FDA at 1-800-FDA-1088 or at In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking tadalafil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. at approximately the same time every day ()•ED and BPH: 5 mg, taken at

• Tadalafil 5mg is primarily used to treat erectile dysfunction.
• It works by relaxing blood vessels in the penis.
• Typically taken once daily for ongoing management.

approximately the same time every day (, )•Tadalafil tablets may be taken without regard

• Overdose signs include painful erections lasting over 4 hours.
• Seek immediate medical attention if overdose is suspected.
• Follow dosage directions strictly to avoid complications.

to food ().DOSAGE FORMS AND STRENGTHSTablets: 2.5 mg, 5 mg, 10 mg, 20 mg ().

Generic vs Brand

Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional.

How does tadalafil work (mechanism of action)?

Always ask your health care professional for complete information about this product and your specific health needs. Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. This copyrighted material has been downloaded from a licensed data provider. The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment. (3)CONTRAINDICATIONS•Administration of tadalafil tablets to patients using any form of organic nitrate is contraindicated.