2 DOSAGE AND ADMINISTRATION

Gunn, A.

Data availability

SOD1 levels also returned to baseline with sildenafil treatment, indicating a reversal of HI-induced oxidative stress (Fig. Similarly, NeuN and synaptophysin expression at P30 were normalized following sildenafil administration (Fig. pAKT levels were decreased significantly at P12 following HI (p < 0.05) compared to sham animals but returned to baseline levels after sildenafil treatment (Fig. In our rat model of term neonatal HIE, HI induced sildenafil 5mg for sale an increase in reactive astrocytes and microglia in the cortex adjacent to the infarct boundary, as well as in the white matter, which remained evident 20 days post-insult. The number of activated, phagocytic macrophages also increased significantly in CC and ECL.

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Interestingly, the anti-inflammatory cytokine IL-1ra was transiently upregulated at P12. Early microglial activation, often associated with an M2 immunomodulatory phenotype, is considered neuroprotective during early brain repair41,42,43,44,45,46. However, persistent microgliosis and sustained pro-inflammatory cytokine expression are linked to oligodendrocyte and neuronal injury47. In line with human and animal data, glial cells and neurons in our model appeared to have released inflammatory cytokines that contributed to ongoing neuroinflammation48,49,50,51,52,53. Reactive astrocytes, infiltrating the injured brain after HI, further amplified the inflammatory response54,55,56.

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This chronic inflammatory environment characterizes the tertiary phase of HIE injury, driven by both resident glia and infiltrating peripheral immune cells. Together, they create a toxic niche that hinders white matter maturation, neurogenesis, and synaptogenesis57,58,59. Sildenafil treatment significantly decreased the number of reactive astrocytes and activated microglia in the cortex and white matter. These effects were most prominent with medium and high doses, consistent with previous findings showing a dose-dependent reduction in brain injury and improved neurological outcomes19,20. These data suggest that sildenafil may target the tertiary phase of injury, promoting neurorestoration. J., Gunn, T.

R., de Haan, H.

8.6 Patients with Hepatic Impairment

myelin basic protein, MBP, or Luxol Fast Blue) would provide a more direct assessment of myelin content; however, these stains were not available for the present dataset. The thickness measurements were therefore used as an established histological indicator of white matter atrophy or preservation in this model. Future work should include myelin-specific staining to further confirm these findings. Third, our interpretation of the PI3K/AKT/mTOR pathway modulation as a potential mechanism was based solely on pAKT (Ser473) expression normalized to β-actin, as total AKT data were not available. Ser473 phosphorylation is a well-established marker of AKT activation in neuroprotection studies; however, assessing additional sites, such as Thr308, would provide complementary insights into upstream signaling mechanisms.

Serious side effects

Establishing causality will require studies using selective inhibitors of mTORC1 and mTORC2. Further work should further characterize AKT activation following HI and sildenafil treatment and examine downstream mTOR targets and their crosstalk with inflammatory signaling to clarify the therapeutic actions of sildenafil. Fourth, our study was limited to male rats; given known sex-related differences in brain injury and repair, future research should evaluate sex-specific responses to HI and sildenafil treatment. Last, validation in large animal models is essential, along with investigation into optimal dosing, timing, and duration of treatment for potential clinical translation. In conclusion, sildenafil treatment after HI significantly attenuated neuroinflammation, reduced glial activation and pro-inflammatory cytokine expression, and improved white matter integrity and markers of neurogenesis.

More common

These reparative effects were associated with restoration p-AKT levels and thus involvement of mTOR signaling. By modulating the inflammatory environment, sildenafil appears to promote a more favorable niche for the restoration of neurodevelopmental processes such as myelination, neurogenesis, and synaptogenesis. Further exploration of sildenafil’s impact on long-term myelination, neurogenesis, and functional outcomes will be critical to advancing its potential clinical translation for neonatal HIE. All data generated during this study are included in this published article. Kurinczuk, J. H., Williams, C. E.

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& Gluckman, P.

More about sildenafil

G., Vincer, M. J., Whyte, R. K. & Stinson, D. A. D.

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Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs.

8.5 Geriatric Use

Hypothermia for neonatal hypoxic ischemic encephalopathy: An updated systematic review and meta-analysis. Moderate hypothermia to treat perinatal asphyxial encephalopathy. & Nakajima, W. Neurobiology of hypoxic-ischemic injury in the developing brain. Relationship between evolving epileptiform activity and delayed loss of mitochondrial activity after asphyxia measured by near-infrared spectroscopy in preterm fetal sheep. & Gressens, P.

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Similar anti-inflammatory effects of sildenafil have been observed in adult models of multiple sclerosis, stroke, and hepatic encephalopathy, where it reduced microglial/macrophage activation and pro-inflammatory cytokine release23,25,29,60. Chronic sildenafil citrate 120 mg neuroinflammation contributes to white matter injury by promoting axonal and myelin degeneration61,62,63,64. In our model, persistent neuroinflammation coincided with a reduction in thickness of the CC and ECL by P30. This finding is particularly relevant, since oligodendrocytes are highly susceptible to HI70 and are responsible for myelination during the tertiary phase. White matter injury occurs in nearly one-quarter of term neonates with HIE71 and is associated with adverse long-term neurodevelopmental outcomes72,73.

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Sildenafil treatment restored thickness of the CC and ECL and improved oligodendrocyte populations in a dose-dependent manner. Medium and high doses increased both total (Olig2 +) and mature (CC1 +) oligodendrocyte counts in the CC and ECL, but not immature ones (Olig2 + /CC1-). These findings indicate that sildenafil may promote oligodendrogenesis and support remyelination. Previous studies in adult models of stroke, multiple sclerosis, and diabetes support this hypothesis, demonstrating that sildenafil enhances oligodendrocyte regeneration, increases myelin thickness, and protects myelinated axons by modulating immune responses24,28,29,74. Sildenafil’s effects appear context-dependent, promoting oligodendrocyte maturation primarily under hypoxic-ischemic conditions.

Clinical monitoring

Its anti-inflammatory and pro-survival actions may create a permissive environment for oligodendrocyte maturation and myelin repair during injury, whereas in the absence of HI, these pathways are likely insufficiently activated to elicit further enhancement. In addition to its effects on glial cells, HI reduced the expression of key neuronal and synaptic proteins, including NeuN and synaptophysin. Sildenafil restored their levels to those comparable to sham controls, which suggests neuronal preservation and synaptic repair. These results align with our prior data19 and with studies in adult disease models75,76,77 that report enhanced neuronal survival and increased synaptic protein expression following sildenafil treatment. Furthermore, sildenafil has exhibited notable anti-apoptotic effects. Tertiary mechanisms of brain damage: A new hope for treatment of cerebral palsy?.

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& Charriaut-Marlangue, C.

Inflammatory responses in the cerebral cortex after ischemia in the P7 neonatal Rat.

12.1 Mechanism of Action

J., White-Koning, M. & Badawi, N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Tagin, M. A., Woolcott, C. Adenosine deaminase activity, lipid peroxidation and astrocyte responses in

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the cerebral cortex of rats after neonatal hypoxia ischemia.

Society and culture

While HI induced a marked increase in apoptosis at P12, sildenafil treatment attenuated this response. Together, these results support both a neuroprotective and neurorestorative role for sildenafil, in agreement with prior studies demonstrating its ability to reduce apoptosis in neurons and oligodendrocytes22,78,79,80,81,82,83. Additional immunohistochemistry is required in our model to pinpoint the cell types affected by apoptosis and to determine whether sildenafil selectively mitigated apoptotic injury in oligodendrocytes or neurons. Mechanistically, sildenafil may exert these effects via modulation of the PI3K/AKT/mTOR signaling pathway84. We observed that p-AKT levels were reduced following HI but were restored by sildenafil treatment.

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This restoration likely contributed to the anti-inflammatory and reparative effects of sildenafil, supporting white matter recovery85. This restoration is particularly relevant, since constitutive AKT activation has been shown to enhance myelin production86. Finally, while neuroinflammation is necessary for repair, its persistence can be harmful. Modulating rather than eliminating this response is key. Previous studies using inhaled nitric oxide or sildenafil demonstrated reduced white matter inflammation and enhanced oligodendrocyte maturation in neonatal models87,88.

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Our findings support the therapeutic potential of sildenafil during the tertiary phase, provided that improvements in neurodevelopmental outcomes are confirmed89,90. While our findings provide strong evidence for the neuroprotective and neurorestorative effects of sildenafil in a rat model of term neonatal HIE, several limitations should be considered. First, the present study focused on short- and intermediate-term histological and molecular outcomes up to P30; long-term neurodevelopmental and behavioral assessments are needed to determine whether these structural improvements translate into functional recovery. Second, we assessed the thickness of the corpus callosum (CC) and the left external capsule (ECL) as a morphometric proxy for white matter integrity and myelination. We acknowledge that myelin-specific sildenafil citrate tablets for female staining (e.g.